Association between hantavirus cardiopulmonary syndrome in humans and landscape configuration in the Cerrado region of Minas Gerais, Brazil

Abstract

The objective of this study was to analyze the spatiotemporal distribution of 193 autochthonous cases that were confirmed as hantavirus cardiopulmonary syndrome (HCPS) from 1998 to 2007 and its association with landscape configuration in the Cerrado region of Minas Gerais, Brazil. Among the 193 autochthonous cases, the probable sites of infection (PSI) of 129 cases (66.8%) were geoprocessed. We then evaluated the association between the HCPS cases and landscape variables through a multivariate analysis of the main components. Particularly, the mesoregion of Triângulo Mineiro/Alto Paranaíba had 130 autochthonous cases (67.3%). In addition, the chance of conglomeration of cases in municipalities located in this mesoregion was greater than that in other mesoregions. HCPS cases were positively associated with the increase in the area of planted pastures and natural forests in the Cerrado region. Rice, beans, maize, and sugar cane cultivations were less associated with HCPS. We concluded that the changes in the Cerrado ecosystem due to agricultural activities propitiate the maintenance of rodent populations and HCPS virus reservoirs. Additional training for health professionals for early diagnosis and reduction of the causes of the disease must be carried out in the endemic areas of Minas Gerais.