Does hyperbaric oxygen therapy positively change organic dysfunctions in bitches with sepsis caused by cystic endometrial hyperplasia-pyometra

Auteurs-es

  • Otávio Henrique de Melo Schiefler Programa de Pós-graduação em Medicina Veterinária (PPGMV) em Clínica Cirúrgica de Pequenos Animais, da Universidade Federal de Santa Maria (UFSM), Santa Maria/RS, Brasil https://orcid.org/0000-0001-6723-0861
  • Emanuelle Bortolotto Degregori Programa de Pós-graduação em Medicina Veterinária (PPGMV) em Clínica Cirúrgica de Pequenos Animais, da Universidade Federal de Santa Maria (UFSM), Santa Maria/RS, Brasil https://orcid.org/0000-0002-0547-2504
  • Bernardo Nascimento Antunes Programa de Pós-graduação em Medicina Veterinária (PPGMV) em Clínica Cirúrgica de Pequenos Animais, da Universidade Federal de Santa Maria (UFSM), Santa Maria/RS, Brasil https://orcid.org/0000-0001-6833-0338
  • Pâmela Caye Programa de Pós-graduação em Medicina Veterinária (PPGMV) em Clínica Cirúrgica de Pequenos Animais, da Universidade Federal de Santa Maria (UFSM), Santa Maria/RS, Brasil https://orcid.org/0000-0002-6456-8100
  • Rainer da Silva Reinstein Programa de Pós-graduação em Medicina Veterinária (PPGMV) em Clínica Cirúrgica de Pequenos Animais, da Universidade Federal de Santa Maria (UFSM), Santa Maria/RS, Brasil https://orcid.org/0000-0001-8294-2621
  • Maurício Veloso Brun Departamento de Clínica de Pequenos Animais, Universidade Federal de Santa Maria, Av. Roraima 1000, Camobi, Santa Maria – Rio Grande do Sul, 97105-900, Brasil https://orcid.org/0000-0001-9252-8512
  • Daniel Curvello de Mendonça Müller Departamento de Clínica de Pequenos Animais, Universidade Federal de Santa Maria, Av. Roraima 1000, Camobi, Santa Maria – Rio Grande do Sul, 97105-900, Brasil https://orcid.org/0000-0002-7225-6027

DOI :

https://doi.org/10.21708/avb.2024.18.1.12321

Résumé

Experimental models have shown positive outcomes associated with hyperbaric oxygen therapy (HO) when it comes to reducing mortality rates in sepsis patients. The aim of the present study is to assess HO impact on the microperfusion of sepsis bitches with Cystic Endometrial Hyperplasia-Pyometra (CEH-P) based on SOFA SCORE (Sequential Organ Failure Assessment) to quantify and monitor organic dysfunction degree. Eight (8) bitches diagnosed with CEH-P were included in the study; they were randomly split into two groups: G1 (ovariohysterectomy + clinical therapy) and G2 (ovariohysterectomy + clinical therapy + HO). All bitches in G2 were subjected to three HO sessions, at 24-h time interval between sessions. All animals showed at least one organic dysfunction due to sepsis. Animals in G2 presented significant improvement in clinical conditions and initial 51% reduction in SOFA scoring. On the other hand, animals in G1 recorded 29% reduction in this variable. Hyperbaric therapy was effective in reducing bitches’ organic dysfunction with sepsis caused by CEH-P; however, it did not have significant reflex on Central Venous Oxygen Saturation (SvcO2).

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Figure 1 - Monoplace Hyperbaric Chamber (HVM®) of UFSM University Veterinary Hospital.

Publié-e

2024-03-31

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Original Articles / Artigos de Pesquisa