Metastatic T-cell lymphoma of unknown primary origin in a dog (Canis lupus familiaris)

  • Ramon Tadeu Galvão Alves Rodrigues Programa de Pós-Graduação em Medicina Veterinária/Universidade Federal de Campina Grande
  • Ismael Lira Borges Programa de Pós-Graduação em Medicina Veterinária/Universidade Federal de Campina Grande
  • Telma de Sousa Lima Programa de Pós-graduação em Ciência Animal/ Universidade Federal da Paraíba
  • Mayara Leal Firmino da Silva Médica Veterinária Autônoma, João Pessoa-PB
  • Poliana Araújo Ximenes Médica Veterinária Autônoma, Fortaleza-CE
  • José Artur Brilhante Bezerra Programa de Pós-Graduação em Ciência Animal/Universidade Federal Rural do Semiárido
  • Kilder Dantas Filgueira Hospital Veterinário/Universidade Federal Rural do Semiárido


Canine lymphoma is a hematopoietic neoplasm that can affect different tissues. Its classification is performed according to cellular morphology, clinical stage, immunophenotyping, and anatomical location. However, in some cases, an oncopathy might be in an advanced stage with a plain organic spread, making it impossible to determine the initially affected tissue, which is a rare situation in animals. Thus, a case of metastatic lymphoma, of unknown primary origin, was described in a four-year-old Rottweiler bitch with multiple nodular subcutaneous proliferations. Hematological, biochemical, thoracic radiography, and abdominal ultrasound tests were performed, as well as a cytopathological examination of subcutaneous lesions and bone marrow. Hematologic findings determined anemia, lymphopenia, and thrombocytopenia. The thoracic radiography revealed multiple nodular masses. Cytopathological examination revealed infiltration of malignant lymphocytes into the subcutaneous nodules and into the bone marrow. The dog was euthanized and submitted to necroscopic examination, in which multiple nodules were found in the subcutaneous region, lung, pericardium, gastrointestinal tract and in the skeletal musculature, in addition to lymphadenopathy. Fragments of the affected structures were collected for later histopathological and immunohistochemical evaluation. Histopathological examination revealed the presence of neoplastic cells compatible with diffuse lymphoma, which was positively immunolabelled for T-cell lymphoma. Based on clinical-pathological findings and other complementary tests, a diagnosis of diffuse T-cell lymphoma of unknown primary origin was made. In order to classify hematopoietic neoplasms, it is essential to perform different laboratory tests. However, determination of origin becomes difficult when such an oncological disease presents an advanced stage.


Não há dados estatísticos.
Clinical Reports / Casos Clínicos