Immune plasma of rabbits with acute infection in the control of Trypanosoma evansi parasitemia in experimentally infected rats

Authors

  • Mateus Anderson Otto
  • Aleksandro S Da Silva
  • Lucas Gressler
  • Franciele Bess
  • Letticia Dall Agnol
  • Tayana Sessegolo
  • Patrique Pereira
  • Silvia G Monteiro

DOI:

https://doi.org/10.21708/avb.2010.4.3.1782

Abstract

This study was aimed to compare the effect of fresh and frozen immune plasma of rabbits with acute infection in the prophylactic and curative control of Trypanosoma evansi-infected rats. Thirty adult rats and a rabbit were used. The rabbit was infected with 0.5ml of blood containing trypomastigotes. Showing the parasite in the bloodstream, plasma was obtained and divided in frozen and fresh plasma. Frozen plasma was stored in cryopreservation tubes and frozen. Fresh plasma was kept at 37°C for 30 minutes. The rats were separated into six equal groups, all infected intraperitoneally with 4.5 x 104 trypomastigotes of the T. evansi strain. Each rat from prophylatic (A and B) and curative(C and D) groups received 0.8ml of plasma. Animals from group E (control group) received only saline. Frozen plasma was administered in groups A and C and the fresh plasma in groups B and D. The effects of rabbits plasma with acute infection was estimated by evaluation of the prepatency period, longevity and curative effects of rats. No difference was observed in the prepatency period. The longevity of the animals treated prophylactically with fresh plasma (group B) was superior than the other groups. No curative effect was observed in the animals, but based upon the results it is concluded that the treatment with immune plasma of rabbits increases the longevity of T. evansi-infected rats.

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Published

2010-10-20

Issue

Vol. 4 No. 3 (2010)

Section

Original Articles / Artigos de Pesquisa

License

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